As nurses and APPs are well positioned to educate, support, and coordinate care for patients with multiple myeloma, having insight into the evolving trajectory of the disease will enhance their ability to provide quality patient care and identify and eliminate barriers. Addressing barriers to care remains key in ensuring access to novel therapies and improving quality of life. Having an understanding of the advances and increasing complexity of care of the patient with multiple myeloma will prepare nurses and APPs to effectively advocate for this patient population.